Labisia pumila standardized extract (SKF7®) reduces percentage of waist circumference and waist-to-height ratio in individuals with obesity

Swarna Nantha Y 1 , Vijayasingham S 2 , Adam NL 3 , Vengadasalam P 4 , Ismail M 5 , Ali N 6 Show all authors , Chang LC 7 , Ling LYL 8 , Tee TT 9 , Cheah YH 9

Affiliations 

  • 1 Jeffrey Cheah School of Medicine and Health Sciences, Department of General Practice, Monash University, Sunway Campus, Bandar Sunway, Malaysia
  • 2 Department of Medicine, Clinical Research Centre, Melaka General Hospital, Melaka, Malaysia
  • 3 Department of Medicine, Tuanku Ja'afar Hospital, Clinical Research Centre, Seremban, Malaysia
  • 4 Greentown Primary Healthcare Clinic, Perak, Malaysia
  • 5 Seremban 2 Primary Healthcare Clinic, Seremban, Malaysia
  • 6 Masjid Tanah Primary Healthcare Clinic, Melaka, Malaysia
  • 7 Kuang Primary Healthcare Clinic, Selangor, Malaysia
  • 8 Infinite Stats Consult, Kuala Lumpur, Malaysia
  • 9 ZACH Biotech Depot Sdn Bhd, Kajang, Malaysia
Diabetes Obes Metab, 2023 Nov;25(11):3298-3306.
PMID: 37551550 DOI: 10.1111/dom.15229

Abstract

AIM: Evidence from the literature points towards a viable choice of utilizing Labisia pumila to improve the metabolic profile in animal studies. To that end, this prospective study was designed to assess the health impact of the consumption of L. pumila standardized extract (SKF7®) on key parameters of obesity in humans such as body weight (BW), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR).

MATERIALS AND METHODS: A dose-ranging analysis using SKF7® was conducted through a randomized, double-blind, multicentre, placebo-controlled, phase 2 clinical trial involving individuals with obesity (N = 133) between January 2020 and April 2021. The potential percentage of change was assessed in relation to BW, BMI, WC and WHtR.

RESULTS: Average treatment effect estimates (treatment group vs. placebo) show a statistically significant reduction in the percentage of change for BW (mean = -2.915; CI: -4.546, -1.285), BMI (-2.921; CI: -4.551, -1.291), WC (mean = -2.187; CI: -3.784, -0.589) and WHtR (mean = -2.294, CI: -3.908, -0.681) in the group with a total of 750 mg of SKF7® (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications