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Cyclodextrin nanoparticles in targeted cancer theranostics

Bose R 1 , Jayawant M 1 , Raut R 2 , Lakkakula J 1 , Roy A 3 , Alghamdi S 4 Show all authors , Qusty NF 4 , Sharma R 5 , Verma D 6 , Khandaker MU 7 , Almujally A 8 , Tamam N 9 , Sulieman A 10

Affiliations 

  • 1 Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai, Maharashtra, India
  • 2 Department of Botany, The Institute of Science, Mumbai, Maharashtra, India
  • 3 Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India
  • 4 Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
  • 5 Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • 6 Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India
  • 7 Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Petaling Jaya, Selangor, Malaysia
  • 8 Department of Biomedical Physics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
  • 9 Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
  • 10 Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia
Front Pharmacol, 2023;14:1218867.
PMID: 37601050 DOI: 10.3389/fphar.2023.1218867

Abstract

The field of cancer nanotheranostics is rapidly evolving, with cyclodextrin (CD)-based nanoparticles emerging as a promising tool. CDs, serving as nanocarriers, have higher adaptability and demonstrate immense potential in delivering powerful anti-cancer drugs, leading to promising and specific therapeutic outcomes for combating various types of cancer. The unique characteristics of CDs, combined with innovative nanocomplex creation techniques such as encapsulation, enable the development of potential theranostic treatments. The review here focuses mainly on the different techniques administered for effective nanotheranostics applications of CD-associated complex compounds in the domain of cancer treatments. The experimentations on various loaded drugs and their complex conjugates with CDs prove effective in in vivo results. Various cancers can have potential nanotheranostics cures using CDs as nanoparticles along with a highly efficient process of nanocomplex development and a drug delivery system. In conclusion, nanotheranostics holds immense potential for targeted drug delivery and improved therapeutic outcomes, offering a promising avenue for revolutionizing cancer treatments through continuous research and innovative approaches.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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