Two new flavonols from Macaranga inermis pax & K.Hoffm

Tanjung M 1 , Tjahjandarie TS 1 , Aldin MF 1 , Mardhiyyah S 1 , Saputri RD 2 , Syah YM 3 Show all authors , Ahmat N 4

Affiliations 

  • 1 Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
  • 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia
  • 3 Natural Products Chemistry Research Group, Organic Chemistry Division, Bandung Institute of Technology, Bandung, Indonesia
  • 4 Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia
Nat Prod Res, 2023 Oct 24.
PMID: 37874007 DOI: 10.1080/14786419.2023.2272783

Abstract

Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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