Affiliations 

  • 1 Materials Research & Consultancy Group (MRCG), Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia
  • 2 Advanced Membrane Technology Research Centre, Universiti Teknologi Malaysia, Johor, Malaysia
  • 3 Advanced Facilities Engineering Technology Research Cluster (AFET), Plant Engineering Technology (PETech) Section, Malaysian Institute of Industrial Technology, Universiti Kuala Lumpur, Masai, Johor, Malaysia
  • 4 Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bandar Baru Bangi, Selangor, Malaysia
  • 5 Laboratory of UPM - MAKNA Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
  • 6 Department of Physics, Faculty of Mathematics and Natural Sciences Universitas Negeri Malang, Malang, Indonesia
  • 7 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia
Biotechnol J, 2024 Mar;19(3):e2300464.
PMID: 38509814 DOI: 10.1002/biot.202300464

Abstract

The present study evaluates the corrosion behavior of poly[xylitol-(1,12-dodecanedioate)](PXDD)-HA coated porous iron (PXDD140/HA-Fe) and its cell-material interaction aimed for temporary bone scaffold applications. The physicochemical analyses show that the addition of 20 wt.% HA into the PXDD polymers leads to a higher crystallinity and lower surface roughness. The corrosion assessments of the PXDD140/HA-Fe evaluated by electrochemical methods and surface chemistry analysis indicate that HA decelerates Fe corrosion due to a lower hydrolysis rate following lower PXDD content and being more crystalline. The cell viability and cell death mode evaluations of the PXDD140/HA-Fe exhibit favorable biocompatibility as compared to bare Fe and PXDD-Fe scaffolds owing to HA's bioactive properties. Thus, the PXDD140/HA-Fe scaffolds possess the potential to be used as a biodegradable bone implant.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.