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Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study

Ng DC 1 , Liew CH 2 , Tan KK 3 , Awang EHB 1 , Nazri FNBA 1 , Maran AKT 1 Show all authors , Mohan VAAC 1 , Ramachandran D 2 , Chok M 1 , Teh CH 1 , Mohamad Nor A 1 , Baharuddin SB 1 , Khoo EJ 4

Affiliations 

  • 1 Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia
  • 2 Hospital Tuanku Ampuan Najihah, Ministry of Health Malaysia, Kuala Pilah, Malaysia
  • 3 Department of Paediatrics, Perdana University Seremban Clinical Academic Center, Seremban, Malaysia
  • 4 Department of Paediatrics, International Medical University, Kuala Lumpur, Malaysia
Clin Respir J, 2024 Mar;18(3):e13747.
PMID: 38529669 DOI: 10.1111/crj.13747

Abstract

INTRODUCTION: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children.

METHODS: This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics.

RESULTS: This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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