Thiazole - A promising scaffold for antituberculosis agents and structure-activity relationships studies

Zhao X 1 , Di J 2 , Luo D 3 , Verma R 4 , Verma SK 5 , Verma S 6 Show all authors , Ravindar L 7 , Koshle A 8 , Dewangan HK 8 , Gupta R 8 , Chandra S 8 , Deshpande S 9 , Kamal 10 , Vaishnav Y 6 , Rakesh KP 11

Affiliations 

  • 1 Energy Engineering College, Yulin University, Yulin City 71900, China
  • 2 Physical Education College, Yulin University, Yulin City 71900, China. Electronic address: dj0904@qq.com
  • 3 School of Humanities and Management, Xi'an Traffic Engineering Institute, Xi'an City 710000, China
  • 4 School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, Shaanxi, China
  • 5 School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, Shaanxi, China. Electronic address: vermasantosh08@yulinu.edu.cn
  • 6 Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University) Bilaspur 495009, Chhattisgarh, India
  • 7 Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia
  • 8 Department of Chemistry, Shri Rawatpura Sarkar University, Raipur 492015, Chhattisgarh, India
  • 9 Department of Applied Chemistry, Shri Shankaracharya Technical Campus, Bhilai Durg-490020, Chhattisgarh, India
  • 10 Department of Chemistry, Indian Institute of Technology Jammu, Jammu 181221, India
  • 11 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: rakeshasg@gmail.com
Bioorg Chem, 2024 Dec 07;154:108035.
PMID: 39693926 DOI: 10.1016/j.bioorg.2024.108035

Abstract

Research on thiazole derivatives has been a popular topic in medicine and one of the most active fields in heterocyclic chemistry. Pharmacological and industrial researchers have been studying thiazole-containing derivatives in great detail because they have a lot of biological uses. These compounds are one of the best examples of a five-membered heterocyclic compound that has a lot of potential and has had a lot of success in recent decades. Investigating viable hybrid designs utilizing thiazole is critical for the development of new anti-tuberculosis medications. This article offers a thorough overview of the latest advancements in thiazole-containing hybrids, offering potential therapeutic applications as anti-TB drugs. We also discussed the structure-activity correlations (SAR) of the powerful thiazole moiety and its several functional groups, along with a few potential molecular targets.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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