High Rates of "Watch" and "Reserve" Class Antibiotics Used to Treat Infections in Neonates and Infants in Southeast Asia

Harrison ML 1 , Dickson BFR 1 , Villanueva-Uy MET 2 , Dwi Putri N 3 , Adrizain R 4 , Kartina L 5 Show all authors , Gunaratna GPS 6 , Chandrasiri NS 7 , Tran HT 8 , Nguyen HX 9 , Fong SM 10 , Kasahara ES 11 , Le CHM 8 , Soekardja D 3 , Husada D 5 , Hong NB 10 , Williams PCM 1

Affiliations 

  • 1 From the Sydney Institute for Infectious Diseases, The University of Sydney
  • 2 Institute of Child Health and Human Development, National Institutes of Health
  • 3 Faculty of Medicine, Universitas Indonesia
  • 4 Department of Child Health, Faculty of Medicine, Universitas Padjadjaran
  • 5 Faculty of Medicine, University of Airlangga
  • 6 Faculty of Medicine, University of Kelaniya
  • 7 Department of Microbiology
  • 8 Department of Neonatology, Da Nang Hospital for Women and Children, Neonatal Unit
  • 9 Department of Public Health, Center for Scientific Research and International Collaboration, Phan Chau Trinh University, Quang Nam, Vietnam
  • 10 Department of Paediatrics, Sabah Women's and Children's Hospital, Sabah, Malaysia
  • 11 Department of Neonatology, Philippine General Hospital, Manila, Philippines
Pediatr Infect Dis J, 2025 Apr 01;44(4):e113-e116.
PMID: 39961140 DOI: 10.1097/INF.0000000000004614

Abstract

We evaluated antibiotic prescribing practices for neonates and infants hospitalized with infections in resource-constrained healthcare settings, where antimicrobial resistance is responsible for significant neonatal morbidity and mortality. A point prevalence survey of 667 admitted infants across 10 clinical sites in Southeast Asia revealed a total of 405 antibiotics were prescribed to 218 infants, with high use of World Health Organization-classified "Watch," "Reserve" and "Not Recommended" antibiotics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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