Waterborne zinc mitigates cadmium-induced toxicity in the mud crab (Scylla paramamosain) through regulation of bioaccumulation, oxidative stress, and lipid metabolism

Waqas W 1 , Yuan Y 2 , Dildar T 2 , Wu C 2 , Ullah A 2 , Shah SAUR 2 Show all authors , Ikhwanuddin M 3 , Ma H 4

Affiliations 

  • 1 Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China; Department of Mathematics, Shantou University, Shantou, 515821, China; International Joint Research Center for the Development and Utilization of Important Mariculture Varieties Surrounding the South China Sea Region, Shantou University, Shantou, 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou, 515063, China
  • 2 Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China; International Joint Research Center for the Development and Utilization of Important Mariculture Varieties Surrounding the South China Sea Region, Shantou University, Shantou, 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou, 515063, China
  • 3 Higher Institute Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, Kuala Nerus, 21030, Malaysia
  • 4 Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China; International Joint Research Center for the Development and Utilization of Important Mariculture Varieties Surrounding the South China Sea Region, Shantou University, Shantou, 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou, 515063, China. Electronic address: mahy@stu.edu.cn
Mar Pollut Bull, 2026 Dec;233(Pt 2):120231.
PMID: 42579921 DOI: 10.1016/j.marpolbul.2026.120231

Abstract

This study assessed the protective effects of zinc (Zn) against cadmium (Cd) toxicity in mud crabs, focusing on metal accumulation, tissue damage, antioxidant responses, fatty acid composition, and gene expression. Cd exposure resulted in significantly elevated metal concentrations, predominantly in the hepatopancreas, followed by gills and muscle tissues (P 

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