Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia
Bioorg Med Chem Lett, 2013 Dec 1;23(23):6280-5.
PMID: 24144849 DOI: 10.1016/j.bmcl.2013.09.082

Abstract

The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.