• 1 a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia
  • 2 c Energy and Environment Unit, Engineering & Processing Division, Malaysian Palm Oil Board , Kajang , Malaysia
  • 3 d Centre of Applied Science Studies , Universiti Teknologi Mara , Kuching , Malaysia
Nat Prod Res, 2018 Nov;32(21):2565-2570.
PMID: 29355031 DOI: 10.1080/14786419.2018.1428588


A phytochemical study carried out on the plant, Calophyllum wallichianum has led to the isolation of a new coumarin, wallimarin T (1) and a known coumarin, calanolide E (2) along with two common triterpenes, friedelin (3) and stigmasterol (4). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the Bacillus bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound 2 was weakly inhibitory towards the Bacilli strains with MIC values ranging from 0.25-0.50 mg/mL. Wallimarin T (1) was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound 2 was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of Bacillus megaterium, Bacillus cereus, Bacillus pumilus and Bacillus subtilis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.