Affiliations 

  • 1 Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA, Jengka, Pahang, Malaysia
  • 2 Centre for Drug Research, Universiti Sains Malaysia, Pulau Pinang, Malaysia
  • 3 Faculty of Science and Marine Environment, University Malaysia Terengganu, Kuala Nerus, Malaysia
  • 4 Centre of Applied Science Studies, Universiti Teknologi Mara, Kuching, Sarawak, Malaysia
  • 5 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Malaysia
Nat Prod Res, 2020 Sep 09.
PMID: 32901512 DOI: 10.1080/14786419.2020.1819273

Abstract

Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC50 value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC50 value of 6.45 ± 0.15 µg/mL.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.