A new coumarin from stem bark of Mesua hexapetala

Karunakaran T 1 , Ee GC 1 , Teh SS 1 , Daud S 1 , Mah SH 2 , Lim CK 3 Show all authors , Jong VY 4 , Awang K 5

Affiliations 

  • 1 a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia
  • 2 c School of Biosciences , Taylor's University , Subang Jaya , Malaysia
  • 3 d Faculty of Science, Department of Chemical Sciences , Universiti Tunku Abdul Rahman , Kampar , Malaysia
  • 4 e Centre of Applied Science Studies , Universiti Teknologi MARA , Kuching , Malaysia
  • 5 f Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur , Malaysia
Nat Prod Res, 2016 Jul;30(14):1591-7.
PMID: 26710827 DOI: 10.1080/14786419.2015.1120727

Abstract

A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications