Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang, Selangor, Malaysia / School of Bioscience, Taylor's University, Lakeside Campus, Subang Jaya, Selangor, Malaysia
  • 2 Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang, Selangor, Malaysia
Pak J Pharm Sci, 2015 Mar;28(2):425-9.
PMID: 25730799

Abstract

Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells (Raji), colon carcinoma cells (LS174T), human neuroblastoma cells (IMR-32) and skin carcinoma cells (SK-MEL-28). The eleven chemical constituents were obtained naturally from the stem bark of Calophyllum inophyllum and Calophyllum soulattri. Inophinnin (1) and inophinone (2) were isolated from Calophyllum inophyllum while soulattrin (3) and phylattrin (4) were found from Calophyllum soulattri. The other xanthones were from both Calophyllum sp. and they are pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7), 4-hydroxyxanthone (8), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). Compound 3 was found to be the most cytotoxic towards all the cancer cell lines with an IC50 value of 1.25μg/mL while the simplest xanthone, compound 8 was inactive.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.