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Blastic plasmacytoid dendritic cell neoplasm in an elderly woman

Foong HBB 1 , Chong M 2 , Taylor EM 3 , Carlson JA 4 , Petrella T 5

Affiliations 

  • 1 Henry Foong Boon Bee, MBBS, FRCP. Universiti Kuala Lumpur Royal College of Medicine Perak, Department of Medicine, No. 3, Jalan Greentown, Ipoh, Perak 30450 Malaysia. bbfoong@pc.jaring.my
  • 2 Chong M. Medical Student, University of Manchester, Manchester, United Kingdom.
  • 3 Taylor E M, MBBS, GDFPD. Foong Skin Specialist Clinic, 33A Persiaran Pearl, Fair Park, Ipoh 31400, Malaysia.
  • 4 Carlson J A, MD. Divisions of Dermatology and Dermatopathology, Albany Medical College, MC-81, Albany, NY 12208, USA.
  • 5 T Petrella, MD. Department of Pathology, CHU Dijon, PTB, 2 rue Angélique Ducoudray, Dijon, France.
Med J Malaysia, 2013 Apr;68(2):161-3.
PMID: 23629565 MyJurnal

Abstract

Blastic plasmacytoid dendritic cell neoplasm (a.k.a. NK cell lymphoma, CD4+CD56+ haematodermic neoplasm) is a rare aggressive tumour that arises from plasmacytoid dendritic cell precursors. We report the first case from Malaysia of a 79-year-old Chinese woman who presented with purpuric plaques and nodules produced by pleomorphic CD4+, CD56+, CD68+, CD123+ and CD303+, but CD2APmononuclear cell infiltrates. Leukemic dissemination occurred and she succumbed to disease without treatment 4 weeks after diagnosis and 9 months after onset of cutaneous disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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