Genetic Association of TCF4 and AKT1 Gene Variants with the Age at Onset of Schizophrenia

Chow TJ 1 , Tee SF , Yong HS , Tang PY

Affiliations 

  • 1 Department of Mechatronics and Biomedical Engineering, Lee Kong Chian Faculty of Engineering and Science, Tunku Abdul Rahman University, Kajang, Malaysia
Neuropsychobiology, 2016;73(4):233-240.
PMID: 27305091

Abstract

Age at onset (AAO) is a known prognostic indicator for schizophrenia and is hypothesized to correlate with cognition and symptom severity. TCF4 and AKT1 are schizophrenia risk genes involved in cognitive functions. The current study examined the interactive effects of TCF4 and AKT1 variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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