No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis

Loh HC 1 , Chow TJ , Tang PY , Yong HS

Affiliations 

  • 1 Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia. Electronic address: hcloh@utar.edu.my
Psychiatry Res, 2013 Oct 30;209(3):732-3.
PMID: 23747160 DOI: 10.1016/j.psychres.2013.05.017

Abstract

We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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