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Mutations of pvdhfr and pvdhps genes in vivax endemic-malaria areas in Kota Marudu and Kalabakan, Sabah

Sastu UR 1 , Abdullah NR 2 , Norahmad NA 3 , Saat MN 4 , Muniandy PK 5 , Jelip J 6 Show all authors , Tikuson M 7 , Yusof N 8 , Sidek HM 9

Affiliations 

  • 1 Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. umie_1902@yahoo.com.my
  • 2 Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. noorrain@imr.gov.my
  • 3 Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. azrina@imr.gov.my
  • 4 Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. mnfarhan@imr.gov.my
  • 5 Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. prem_khs@hotmail.com
  • 6 Sabah State Health Department, Level 3, Rumah Persekutuan, Jalan Mat Salleh, 88590, Kota Kinabalu, Sabah, Malaysia. drjenarun@gmail.com
  • 7 District Health Office Kota Marudu, PO Box 421, 89108, Kota Marudu, Sabah, Malaysia. tmoizin@yahoo.com
  • 8 District Health Office Kota Marudu, PO Box 421, 89108, Kota Marudu, Sabah, Malaysia. hazimnsy@yahoo.com
  • 9 Faculty of Science and Technology, School of Bioscience and Biotechnology, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia. hasidahmohdsidek@yahoo.com
Malar J, 2016;15:63.
PMID: 26850038 DOI: 10.1186/s12936-016-1109-9

Abstract

Malaria cases persist in some remote areas in Sabah and Sarawak despite the ongoing and largely successful malaria control programme conducted by the Vector Borne Disease Control Programme, Ministry Of Health, Malaysia. Point mutations in the genes that encode the two enzymes involved in the folate biosynthesis pathway, dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes confer resistance to pyrimethamine and sulfadoxine respectively, in both Plasmodium falciparum and P. vivax. The aim of the current study was to determine the mutation on both pvdhfr at codon 13, 33, 57, 58, 61, 117, and 173 and pvdhps genes at codon 383 and 553, which are potentially associated with resistance to pyrimethamine and sulfadoxine in P. vivax samples in Sabah.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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