Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains

Aydın Tekdaş D 1 , Viswanathan G 2 , Zehra Topal S 1 , Looi CY 3 , Wong WF 4 , Min Yi Tan G 4 Show all authors , Zorlu Y 1 , Gürek AG 1 , Lee HB 2 , Dumoulin F 1

Affiliations 

  • 1 Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr
  • 2 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hongboonlee@um.edu.my
  • 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Org Biomol Chem, 2016 Mar 7;14(9):2665-70.
PMID: 26831779 DOI: 10.1039/c5ob02477c

Abstract

A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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