Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300

Kamaruzzaman NF 1 , Firdessa R 2 , Good L 3

Affiliations 

  • 1 Department of Pathology and Pathogen Biology, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Locked Bag 36, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia
  • 2 Institute for Molecular Infection Biology, Josef-Schneider-Str. 2/D15, University of Würzburg, 97080 Würzburg, Germany
  • 3 Department of Pathology and Pathogen Biology, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK lgood@rvc.ac.uk
J Antimicrob Chemother, 2016 May;71(5):1252-9.
PMID: 26825118 DOI: 10.1093/jac/dkv474

Abstract

The treatment of skin infections caused by Staphylococcus aureus is limited by acquired antibiotic resistance and poor drug delivery into pathogen and host cells. Here, we investigated the antibacterial activities of six topically used antimicrobials and a cationic polymer, polyhexamethylene biguanide (PHMB), against intracellular MSSA strain RN4420 and MRSA strains EMRSA-15 and USA 300.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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