In vitro and in vivo anti-inflammatory activity of 17-O-acetylacuminolide through the inhibition of cytokines, NF-κB translocation and IKKβ activity

Achoui M; Appleton D; Abdulla MA; Awang K; Mohd MA; Mustafa MR

doi:10.1371/journal.pone.0015105

Fulltext

In vitro and in vivo anti-inflammatory activity of 17-O-acetylacuminolide through the inhibition of cytokines, NF-κB translocation and IKKβ activity

Achoui M ¹ , Appleton D , Abdulla MA , Awang K , Mohd MA , Mustafa MR

Affiliations

¹ Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia

PLoS One, 2010;5(12):e15105.

PMID: 21152019 DOI: 10.1371/journal.pone.0015105

Abstract

17-O-acetylacuminolide (AA), a diterpenoid labdane, was isolated for the first time from the plant species Neouvaria foetida. The anti-inflammatory effects of this compound were studied both in vitro and in vivo.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.