Green-synthesised nanoparticles from Melia azedarach seeds and the cyclopoid crustacean Cyclops vernalis: an eco-friendly route to control the malaria vector Anopheles stephensi?

Anbu P 1 , Murugan K 1 , Madhiyazhagan P 1 , Dinesh D 1 , Subramaniam J 1 , Panneerselvam C 1 Show all authors , Suresh U 1 , Alarfaj AA 2 , Munusamy MA 2 , Higuchi A 3 , Hwang JS 4 , Kumar S 5 , Nicoletti M 6 , Benelli G 7

Affiliations 

  • 1 a Division of Entomology, Department of Zoology , School of Life Sciences, Bharathiar University , Coimbatore , India
  • 2 b Department of Botany and Microbiology , College of Science, King Saud University , Riyadh , Saudi Arabia
  • 3 c Department of Chemical and Materials Engineering , National Central University , Taoyuan , Taiwan
  • 4 d Institute of Marine Biology , National Taiwan Ocean University , Keelung , Taiwan
  • 5 e Faculty of Medicine and Health Sciences, Department of Medical Microbiology and Parasitology , University Putra Malaysia , Serdang , Malaysia
  • 6 f Department of Environmental Biology , Sapienza University of Rome , Rome , Italy
  • 7 g Department of Agriculture, Food and Environment , University of Pisa , Pisa , Italy
Nat Prod Res, 2016 Sep;30(18):2077-84.
PMID: 26679526 DOI: 10.1080/14786419.2015.1114935

Abstract

The impact of green-synthesised mosquitocidal nanoparticles on non-target aquatic predators is poorly studied. In this research, we proposed a single-step method to synthesise silver nanoparticles (Ag NP) using the seed extract of Melia azedarach. Ag NP were characterised using a variety of biophysical methods, including UV-vis spectrophotometry, scanning electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy. In laboratory assays on Anopheles stephensi, Ag NP showed LC50 ranging from 2.897 (I instar larvae) to 14.548 ppm (pupae). In the field, the application of Ag NP (10 × LC50) lead to complete elimination of larval populations after 72 h. The application of Ag NP in the aquatic environment did not show negative adverse effects on predatory efficiency of the mosquito natural enemy Cyclops vernalis. Overall, this study highlights the concrete possibility to employ M. azedarach-synthesised Ag NP on young instars of malaria vectors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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