Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis

Tan HL 1 , Mohamed R , Mohamed Z , Zain SM

Affiliations 

  • 1 aThe Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya bDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Pharmacogenet Genomics, 2016 Feb;26(2):88-95.
PMID: 26636496 DOI: 10.1097/FPC.0000000000000193

Abstract

Phosphatidylethanolamine N-methyltransferase (PEMT) governs the secretion of hepatic triglycerides in the form of very low-density lipoprotein and has been implicated in nonalcoholic fatty liver disease (NAFLD). Studies on the role of the PEMT rs7946 polymorphism as a genetic modifier of NAFLD have reported inconsistent results. This meta-analysis was carried out to evaluate and summarize the association of PEMT rs7946 with susceptibility to NAFLD.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications