Comprehensive evaluation of the neuropeptide-Y gene variants in the risk of obesity: a case-control study and meta-analysis

Zain SM 1 , Mohamed Z , Jalaludin MY , Fauzi F , Hamidi A , Zaharan NL

Affiliations 

  • 1 aThe Pharmacogenomics Laboratory bDepartment of Pharmacology cDepartment of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Pharmacogenet Genomics, 2015 Oct;25(10):501-10.
PMID: 26240981 DOI: 10.1097/FPC.0000000000000164

Abstract

Orexigenic actions mediated by neuropeptide-Y (NPY) promote body weight regulation. Genetic variations in the NPY gene could therefore influence susceptibility to obesity, but results have been conflicting. We have carried out, for the first time, a case-control study to examine the effect of NPY rs16147 and rs5574 variants with the risk of obesity in Asians and also a meta-analysis to summarize the effect of these variants including that of the widely studied rs16139.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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