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Haemophagocytic syndrome presenting as pyrexia of unknown origin

Fadilah SA 1 , Raymond AA 2 , Leong CF 3 , Cheong SK 3

Affiliations 

  • 1 Clinical Haematology and Stem Cell Transplantation Services, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia
  • 2 Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia
  • 3 Clinical Haematology and Stem Cell Transplantation Services, Hospital Universiti Kebangsaan Malaysia (HUKM), Kuala Lumpur
Med J Malaysia, 2006 Mar;61(1):91-3.
PMID: 16708741

Abstract

Haemophagocytic syndrome (HPS) should be included in the differential diagnosis of pyrexia of unknown origin (PUO). The hallmark of HPS is the accumulation of activated macrophages that engulf haematopoietic cells in the reticuloendothelial system. We describe a patient with unexplained fever in which a final diagnosis of HPS was established in a bone marrow study.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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