Affiliations 

  • 1 Cell Therapy Center, Universiti Kebangsaan Malaysia Medical Center, 56000 Kuala Lumpur, Malaysia. Electronic address: wanfariza@ppukm.ukm.edu.my
  • 2 Department of Medicine (Infectious Disease), Universiti Kebangsaan Malaysia Medical Center, 56000 Kuala Lumpur, Malaysia. Electronic address: petrick@ppukm.ukm.edu.my
  • 3 Department of Anaesthesiology and Intensive Care, Universiti Kebangsaan Malaysia Medical Center, 56000 Kuala Lumpur, Malaysia. Electronic address: docaweng@yahoo.com
  • 4 Cell Therapy Center, Universiti Kebangsaan Malaysia Medical Center, 56000 Kuala Lumpur, Malaysia. Electronic address: sfadilah@ppukm.ukm.edu.my
J Clin Virol, 2015 Aug;69:91-5.
PMID: 26209387 DOI: 10.1016/j.jcv.2015.06.004

Abstract

Infection associated hemophagocytic syndrome is increasingly recognized as a potentially fatal complication of dengue fever. It should be suspected with prolonged fever beyond seven days associated with hepatosplenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. Surge of similar pro-inflammatory cytokines observed in dengue associated hemophagocytic syndrome and multiorgan dysfunction may indicate they are part of related inflammatory spectrum. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report three cases of dengue associated IAHS with good outcome following early recognition and treatment with dexamethasone and intravenous immunoglobulin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.