Affiliations 

  • 1 Sunway University College, Bandar Sunway, 46150, P.J. Selangor, Malaysia
Bioorg Med Chem Lett, 2006 Jun 15;16(12):3337-40.
PMID: 16621533

Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.