Affiliations 

  • 1 Pharmacogenetics Study Group, Department of Pharmacology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
J Clin Pharm Ther, 2004 Feb;29(1):47-52.
PMID: 14748897 DOI: 10.1046/j.1365-2710.2003.00535.x

Abstract

Polymorphism of the beta2-adrenergic receptor (beta2 AR) gene is an important determinant of the function of this receptor. It affects receptor down-regulation and beta2-agonist responses. It has also been a focus of interest in attempts to elucidate the genetic basis of asthma, hypertension, obesity and cystic fibrosis. Several different techniques have been established to determine beta2 AR genotypes but none of these methods are simple enough to detect simultaneously all the five alleles of our research interest (Arg16/Gly16, -20T/C, Gln27/Glu27, -47T/C and Thr164/Ile164).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.