Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids

Kam TS 1 , Subramaniam G , Sim KM , Yoganathan K , Koyano T , Toyoshima M Show all authors , Rho MC , Hayashi M , Komiyama K

Affiliations 

  • 1 Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia
Bioorg Med Chem Lett, 1998 Oct 06;8(19):2769-72.
PMID: 9873619

Abstract

A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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