Thermoseparating aqueous two-phase systems: Recent trends and mechanisms

Leong YK 1 , Lan JC 2 , Loh HS 3 , Ling TC 4 , Ooi CW 5 , Show PL 1

Affiliations 

  • 1 Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih, Selangor Darul Ehsan, Malaysia
  • 2 Biorefinery and Bioprocess Engineering Laboratory, Department of Chemical Engineering and Material Science, Yuan Ze University, Chungli, Taoyuan, Taiwan
  • 3 School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih, Selangor Darul Ehsan, Malaysia
  • 4 Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 5 Chemical Engineering, School of Engineering, Monash University, Bandar Sunway, Selangor, Malaysia
J Sep Sci, 2016 Feb;39(4):640-7.
PMID: 26447739 DOI: 10.1002/jssc.201500667

Abstract

Having the benefits of being environmentally friendly, providing a mild environment for bioseparation, and scalability, aqueous two-phase systems (ATPSs) have increasingly caught the attention of industry and researchers for their application in the isolation and recovery of bioproducts. The limitations of conventional ATPSs give rise to the development of temperature-induced ATPSs that have distinctive thermoseparating properties and easy recyclability. This review starts with a brief introduction to thermoseparating ATPSs, including its history, unique characteristics and advantages, and lastly, key factors that influence partitioning. The underlying mechanism of temperature-induced ATPSs is covered together with a summary of recent applications. Thermoseparating ATPSs have been proven as a solution to the demand for economically favorable and environmentally friendly industrial-scale bioextraction and purification techniques.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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