Estrogen receptor (ER)-α, β and progesterone receptor (PR) mediates changes in relaxin receptor (RXFP1 and RXFP2) expression and passive range of motion of rats' knee

Dehghan F 1 , Yusof A 2 , Muniandy S 3 , Salleh N 4

Affiliations 

  • 1 Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Exercise Science, Sports Centre, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: fir_dhn@yahoo.com
  • 2 Department of Exercise Science, Sports Centre, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: naguib.salleh@yahoo.com
Environ Toxicol Pharmacol, 2015 Nov;40(3):785-91.
PMID: 26447688 DOI: 10.1016/j.etap.2015.09.004

Abstract

The high risk of knee injuries in female may be associated with sex-steroid hormone fluctuations during the menstrual cycle by its effect on ligaments and tendons stiffness. This study examined changes in knee range of motion in presence of estrogen and progesterone and investigated the interaction of their antagonists to relaxin receptors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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