First isolation of Candida wangnamkhiaoensis from the blood of immunocompromised paediatric patient

Tap RM 1 , Ho Betty LS 2 , Ramli NY 3 , Suppiah J 4 , Hashim R 3 , Sabaratnam P 3 Show all authors , Ginsapu SJ 3 , Gowbei A 5 , Razak MF 3 , Sipiczki M 6 , Ahmad N 3

Affiliations 

  • 1 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia. ratna@imr.gov.my
  • 2 Haematology-Oncology Unit, Paediatric Department, Sarawak General Hospital, Kuching, Sarawak, Malaysia
  • 3 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 4 Virology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 5 Microbiology Unit, Pathology Department, Sarawak General Hospital, Kuching, Sarawak, Malaysia
  • 6 Department of Genetics and Applied Microbiology, University of Debrecen, Debrecen, Hungary
Mycoses, 2016 Nov;59(11):734-741.
PMID: 27427490 DOI: 10.1111/myc.12509

Abstract

Candida wangnamkhiaoensis is a species clustered under the Hyphopichia clade has not ever been isolated from any clinical specimens. To the best of our knowledge, this is the first report of C. wangnamkhiaoensis associated with fungaemia in immunocompromised paediatric patient. The isolate was assigned a strain name as UZ1679/14, in which the identification was confirmed by a polymerase chain reaction-sequencing of the internal transcribed spacer (ITS) and large subunit (LSU) regions of the rRNA gene. Antifungal susceptibility pattern showed that the isolate was sensitive to anidulafungin, caspofungin, fluconazole and voriconazole. The patient clinically improved after the antifungal treatment with caspofungin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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