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A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

Mohd Tap R 1 , Lim TC 2 , Kamarudin NA 3 , Ginsapu SJ 3 , Abd Razak MF 3 , Ahmad N 3 Show all authors , Amran F 3

Affiliations 

  • 1 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Jalan Pahang, 50588, Kuala Lumpur, Malaysia. ratna@imr.gov.my
  • 2 Haematology Unit, Hospital Raja Permaisuri Bainun, Jalan Hospital, 30990, Ipoh, Perak, Malaysia
  • 3 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Jalan Pahang, 50588, Kuala Lumpur, Malaysia
Mycopathologia, 2018 Jun;183(3):559-564.
PMID: 29383574 DOI: 10.1007/s11046-018-0244-y

Abstract

We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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