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First Two Cases of Fungal Infections Associated with Multi-drug Resistant Yeast, Fereydounia khargensis

Tap RM 1 , Ramli NY 2 , Sabaratnam P 2 , Hashim R 2 , Bakri AR 3 , Bee LB 4 Show all authors , Ginsapu SJ 2 , Ahmad R 5 , Razak MF 2 , Ahmad N 2

Affiliations 

  • 1 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia. ratna@imr.gov.my
  • 2 Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia
  • 3 Microbiology Unit, Pathology Department, Queen Elizabeth Hospital, 88200, Kota Kinabalu, Sabah, Malaysia
  • 4 Microbiology Unit, Pathology Department, Sultanah Fatimah Specialist Hospital, 84000, Muar, Johor, Malaysia
  • 5 Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, 50588, Malaysia
Mycopathologia, 2016 Aug;181(7-8):531-7.
PMID: 27010640 DOI: 10.1007/s11046-016-0002-y

Abstract

The number of new fungal pathogens is increasing due to growing population of immunocompromised patients and advanced identification techniques. Fereydounia khargensis is a yeast and was first described in 2014 from environmental samples. As far as we know, this is the first report of human infections associated with F. khargensis. The yeasts were isolated from blood of a HIV-positive patient and pleural fluid of chronic renal failure patient. Amplification and sequencing of the internal transcribed spacer and the large subunit regions confirmed the identity of the isolates. Both isolates showed multi-drug resistance to antifungal agents tested.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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