Anti-inflammatory trends of new benzimidazole derivatives

Bukhari SN 1 , Lauro G 2 , Jantan I 1 , Fei Chee C 3 , Amjad MW 1 , Bifulco G 2 Show all authors , Sher H 4 , Abdullah I 3 , Rahman NA 3

Affiliations 

  • 1 Drug & Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
  • 2 Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy
  • 3 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Center for Plants Sciences & Biodiversity, University of Swat, Swat, Pakistan
Future Med Chem, 2016 Oct;8(16):1953-1967.
PMID: 27654499

Abstract

In present study, the anti-inflammatory activities of a new series of benzimidazole derivatives were studied, investigating their inhibition of secretory phospholipase A2, lipoxygenase, COXs and lipopolysaccharide-induced secretion of TNF-α and IL-6 in mouse RAW264.7 macrophages.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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