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Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines

Hussein WM 1 , Mukaida S 1 , Azmi F 2 , Bartlett S 1 , Olivier C 1 , Batzloff MR 3 Show all authors , Good MF 3 , Skwarczynski M 1 , Toth I 4

Affiliations 

  • 1 School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia
  • 2 School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Faculty of Pharmacy, National University of Malaysia, Kuala Lumpur, Malaysia
  • 3 Institute for Glycomics, Griffith University , Gold Coast, QLD 4215, Australia
  • 4 School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia
ACS Med Chem Lett, 2017 Feb 09;8(2):227-232.
PMID: 28197317 DOI: 10.1021/acsmedchemlett.6b00453

Abstract

Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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