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Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp

Phan CS 1 , Ng SY 2 , Kim EA 3 , Jeon YJ 4 , Palaniveloo K 5 , Vairappan CS 6

Affiliations 

  • 1 Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. yuna123@hotmail.my
  • 2 Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. sheanyeaw90@hotmail.com
  • 3 Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea. yellow6798@hanmail.net
  • 4 Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea. youjinj@jejunu.ac.kr
  • 5 Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. kishneth@yahoo.com
  • 6 Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my
Mar Drugs, 2015 May;13(5):3103-15.
PMID: 25996100 DOI: 10.3390/md13053103

Abstract

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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