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Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Steinig EJ 1 , Andersson P 2 , Harris SR 3 , Sarovich DS 4 , Manoharan A 5 , Coupland P 6 Show all authors , Holden MT 7 , Parkhill J 8 , Bentley SD 9 , Robinson DA 10 , Tong SY 11

Affiliations 

  • 1 Menzies School of Health Research, Darwin, Northern Territory, Australia. eike.steinig@menzies.edu.au
  • 2 Menzies School of Health Research, Darwin, Northern Territory, Australia. patiyan.andersson@menzies.edu.au
  • 3 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. sh16@sanger.ac.uk
  • 4 Menzies School of Health Research, Darwin, Northern Territory, Australia. derek.sarovich@menzies.edu.au
  • 5 Pushpagiri Research Center, Pushpagiri Institute of Medical Sciences and Research Center, Thiruvalla, India. anandmanoharan@pushapagiri.in
  • 6 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. pc10@sanger.ac.uk
  • 7 School of Medicine, University of St. Andrews, St. Andrews, UK. mtgh@st-andrews.ac.uk
  • 8 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. parkhill@sanger.ac.uk
  • 9 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. stephen.bentley@sanger.ac.uk
  • 10 Department of Microbiology, University of Mississippi Medical Center, Jackson, MS, USA. darobinson@umc.edu
  • 11 Menzies School of Health Research, Darwin, Northern Territory, Australia. steven.tong@menzies.edu.au
BMC Genomics, 2015;16:388.
PMID: 25981586 DOI: 10.1186/s12864-015-1599-9

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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