Extracapsular spread (ECS) is one of the most important prognostic factors in oral
squamous cell carcinoma (OSCC). Gamma Glutamyl Hydrolase (GGH) is a lysosomal enzyme which is involved in folate homeostasis. It is overexpressed in several human malignancies but its role in
OSCC has never been reported. Carbonic Anhydrase 9 (CA9) is a transmembrane glycoprotein and is
related to hypoxia. High expression of CA9 has been associated with poor prognosis in several
tumours including OSCC. This study was aimed to investigate the expression of GGH and CA9 in
OSCC and their potential use as biomarkers to predict ECS. (Copied from article).