Fulltext

Gold Nanoparticle-Conjugated Cinnamic Acid Exhibits Antiacanthamoebic and Antibacterial Properties

Anwar A 1 , Siddiqui R 1 , Shah MR 2 , Khan NA 3

Affiliations 

  • 1 Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor, Malaysia
  • 2 HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  • 3 Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor, Malaysia naveed5438@gmail.com
Antimicrob Agents Chemother, 2018 09;62(9).
PMID: 29967024 DOI: 10.1128/AAC.00630-18

Abstract

trans-Cinnamic acid (CA) is a natural organic compound. Using amoebicidal assays, for the first time we showed that CA affected the viability of the protist pathogen Acanthamoeba castellanii Conjugation with gold nanoparticles (AuNPs) enhanced the antiamoebic effects of CA. CA-coated AuNPs (CA-AuNPs) also exhibited significant excystation and encystation activity, compared to CA and AuNPs alone. Pretreatment of amoebae with CA-AuNPs inhibited A. castellanii-mediated host cell cytotoxicity. Moreover, CA-AuNPs exhibited potent effects against methicillin-resistant Staphylococcus aureus and neuropathogenic Escherichia coli K1 and protected host cells against bacteria-mediated host cell death.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications