The purpose of this paper is to prepare a conceptual framework of hybrid lean and ergonomics for assembly manufacturing process based. The research used PDCA approach as a basis in linking the relationship between lean manufacturing and ergonomics. Comprehensive literature review identify the lean ergonomics issues, best practices, and also the way to improve the ergonomic conditions in the workplace, especially those impacting employees on the assembly process. The findings show that the job design strategies for reducing extreme injuries influence by repetitive tasks. Selections of lean tools and technique, human factors analysis and lean performance measure are the key point on the stages of the PDCA conceptual framework for lean ergonomics in working assembly process. This paper also demonstrates by continuous improvement applied between the elimination of waste and increased productivity and the impacts on the ergonomic conditions to carry out operations and consequently by improving the productivity and well-being of its employees based on implementation of PDCA conceptual frameworks.