Fulltext

Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

Costas L 1 , Lujan-Barroso L 2 , Benavente Y 1 , Allen NE 3 , Amiano P 4 , Ardanaz E 4 Show all authors , Besson C 5 , Boeing H 6 , Bueno-de-Mesquita B 7 , Cervenka I 8 , Fortner RT 9 , Fournier A 8 , Gunter M 10 , Harlid S 11 , Huerta JM 4 , Jerkeman M 12 , Jirström K 12 , Kaaks R 9 , Karakatsani A 13 , Khaw KT 14 , Kotanidou A 13 , Lund E 15 , Masala G 16 , Mattiello A 17 , Melin B 11 , Menéndez V 18 , Murphy N 10 , Nieters A 19 , Overvad K 20 , Riboli E 21 , Sacerdote C 22 , Sánchez MJ 4 , Schmidt JA 23 , Sieri S 24 , Tjønneland A 25 , Trichopoulou A 13 , Tumino R 26 , Vermeulen R 27 , Weiderpass E 15 , de Sanjosé S 28 , Agudo A 2 , Casabonne D 1

Affiliations 

  • 1 Unit of Molecular Epidemiology and Genetics in Infections and Cancer, Cancer Epidemiology Research Programme, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain
  • 2 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain
  • 3 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
  • 4 Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain
  • 5 Unit of Hematology-Oncology, Centre Hospitalier de Versailles, Le Chesnay, France
  • 6 German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • 7 Department of Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
  • 8 Centre de Recherche en Epidémiologie et Santé des Populations, Faculté de Médecine-Université Paris-Sud and Faculté de Médecine-Université de Versailles Saint-Quentin-en-Yvelines, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Villejuif, France
  • 9 Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  • 10 International Agency for Research on Cancer, Lyon, France
  • 11 Department of Radiation Sciences, Oncology, Faculty of Medicine, Umeå University, Umeå, Sweden
  • 12 Division of Oncology and Pathology, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden
  • 13 Hellenic Health Foundation, Athens, Greece
  • 14 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
  • 15 Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway
  • 16 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy
  • 17 Dipartimento di Medicina Clinica e Chirugia, Federico II University, Naples, Italy
  • 18 Public Health Directorate, Asturias, Spain
  • 19 Center for Chronic Immunodeficiency at the Center for Translational Cell Research, University of Freiburg Medical Center, Freiburg, Germany
  • 20 Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark
  • 21 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • 22 Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention, Turin, Italy
  • 23 Cancer Epidemiology Unit, Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
  • 24 Epidemiology and Prevention Unit, Fondazione IRCCS-Istituto Nazionale dei Tumori, Milano, Italy
  • 25 Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
  • 26 Cancer Registry and Histopathology Department, Maria Paternò Arezzo Hospital, Ragusa, Italy
  • 27 Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
  • 28 PATH, Seattle, Washington
Am J Epidemiol, 2019 Feb 01;188(2):274-281.
PMID: 30481275 DOI: 10.1093/aje/kwy259

Abstract

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications