Thymoquinone (TQ) is the main pharmacologically active compound found in the seeds oil of Nigella
Sativa. Various studies had been investigated on the therapeutic effects of TQ against several diseases such as
anticancer research, antibacterial, and so on. As a result, a considerable amount of information has been
generated from these researches thus providing a better understanding of the promising effects of this
compound. However, research studies on the potential role of this compound on opioid addiction studies are
still lacking. Therefore, the purpose of this paper is to highlight the potential role of TQ as a non-opioid
substitution therapy in opioid addiction and the chances of this compound to be explored further with special
attention to opioid substitution therapy.