This study addresses lhe association between loneliness and psychological well-being among university students in Malaysia. The study used a multistage cluster sample consisting of 1,467 students who came from five Malaysian universities. Psychological well-being variables in this study were measured through the 12-item General Health Questionnaire scale (GHQ-12) by Golberg (1978). The loneliness variables were measured by using the 14- item Revised UCLA Loneliness Scale by Russell, Peplau and Cutrona (1980). The'cut-off point 5/6' for the GHQ-12 was used to determine the level of psychological well-being among the respondents. Correlation and one-way ANOVA analyses were also done. Generally, the main results showe that about 65.6% of university students in Malaysia indicated a good level of psychological well-being and about 34.4% of university students reported having some psychological problems. In addition, about 59.6% of university students reported having a moderate level of loneliness. Based on the Revised UCLA Loneliness Scale scale, a moderate level of loneliness means these students had a moderate level of satisfaction in interpersonal relationships. Other results of significant tests were obtained. Implications of results are also discussed.