Human neutrophil antigen frequency data for Malays, Chinese and Indians

Hajar CGN 1 , Zulkafli Z 2 , Md Riffin NS 3 , Tuan Mohammad TH 4 , Safuan S 5 , Nelson BR 6 Show all authors , Abdullah MT 6 , Chambers GK 7 , Edinur HA 8

Affiliations 

  • 1 School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia
  • 2 Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia; School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • 3 Hospital Sultan Haji Ahmad Shah, 28000, Temerloh, Pahang Darul Makmur, Malaysia
  • 4 Hospital Seberang Jaya, Perai, Pulau Pinang, Malaysia
  • 5 School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • 6 Institute of Tropical Biodiversity and Sustainable Development, Universiti Malaysia Terengganu, Terengganu, Malaysia
  • 7 School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
  • 8 School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia. Electronic address: edinur@usm.my
Transfus Apher Sci, 2020 Apr;59(2):102651.
PMID: 31606336 DOI: 10.1016/j.transci.2019.09.004

Abstract

BACKGROUND: Human neutrophil antigens (HNAs) are implicated in several clinical disorders and their allelic variations have been reported for many populations. This new study was aimed to report the genotype and alleles frequencies of HNA-1, -3, -4 and -5 loci in Malays, Chinese and Indians in Peninsular Malaysia.

METHODS: A total of 222 blood samples were collected from healthy, unrelated Malay, Chinese and Indian individuals. Their HNA-1, -3 and -4 and HNA-5 loci were genotyped using polymerase chain reaction-sequence specific primer (PCR-SSP) or PCR-restriction fragment length polymorphism (RFLP) assays.

RESULTS: All HNA loci are polymorphic, except for HNA -4. Geneotypes HNA-1a/1b, -3a/3b and -4a/4a were observed most frequently at these three loci in all three ethnic groups. In contrast, HNA-5a/5b and -5a/5a were observed as the predominant genotypes in Malays vs. Chinese and Indians, respectively. The Malays, Chinese and Indians shared HNA -3a (0.505-0.527), HNA -4a (1.000) and -5a (0.676-0.854) as the most frequent alleles. However, HNA-1a was found to be the most common in Malays (0.506) and Chinese (0.504) and HNA-1b for Indians (0.525).

CONCLUSION: Combined with HNA data that have been published for Malay subethnic and Orang Asli groups, this study provides the first fully comprehensive HNA dataset for populations to be found in Peninsular Malaysia. Overall, our findings provide further evidence of genetic complexity in the region. This now publicly available HNA dataset can be used as a reliable reference source for improving medical outcomes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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