• 1 Department of Chemistry, Government College University, Lahore, Pakistan
  • 2 Faculty of Pharmacy &/ Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA, Punca kAlam Campus, Bandar Punca Kalam, Selangor Darul Ehsan, Malaysia
  • 3 Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan
  • 4 Department of Chemistry & Chemical Engineering, SBA School of Sciences & Engineering, Lahore University of Management Sciences, Lahore, Pakistan
Pak J Pharm Sci, 2019 Nov;32(6):2585-2597.
PMID: 31969290


In the study presented here, the nucleophilic substitution reaction of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide was carried out with different alkyl/aralkyl halides (5a-r) to form its different S-substituted derivatives (6a-r), as depicted in scheme 1. The structural confirmation of all the synthesized compounds was done by IR, 1H-NMR, 13C-NMR and CHN analysis data. Bacterial biofilm inhibitory activity of all the synthesized compounds was carried out against Bacillus subtilis and Escherichia coli. The anticancer activity of these molecules was ascertained using anti-proliferation (SRB) assay on HCT 116 Colon Cancer Cell lines while the cytotoxicity of these molecules was profiled for their haemolytic potential. From this investigation it was rational that most of the compounds exhibited suitable antibacterial and anticancer potential along with a temperate cytotoxicity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.