• 1 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia
  • 2 School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Delhi, G.T. Road (NH-1), Phagwara, 144411, Punjab, India
  • 3 School of Life Sciences, University of Technology Sydney, Ultimo, NSW, 2007, Australia
  • 4 School of Phamacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India
  • 5 Saveetha Dental College and Hospitals, Saveetha University, SIMATS, Chennai, Tamilnadu, India
  • 6 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, UK
  • 7 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
  • 8 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak, 124001, India
  • 9 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 12401, India
  • 10 Departamento de Química Orgánica, Facultad de Química Y de Farmacia, Pontificia Universidad Católica de Chile, Av. Vicuña McKenna 4860, 7820436, Santiago, Macul, Chile
  • 11 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara, Punjab, 144411, India
  • 12 Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia
  • 13 School of Science and Health, Western Sydney University, Penrith, NSW, 2751, Australia
  • 14 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan
  • 15 Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW, 2052, Australia
  • 16 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
  • 17 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Inflammopharmacology, 2020 Aug;28(4):795-817.
PMID: 32189104 DOI: 10.1007/s10787-020-00698-3


Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases involve multiple pulmonary components, including airways and lungs that lead to their abnormal physiological functioning. Several signaling pathways have been reported to play an important role in the pathophysiology of respiratory diseases. These pathways, in addition, become the compounding factors contributing to the clinical outcomes in respiratory diseases. A range of signaling components such as Notch, Hedgehog, Wingless/Wnt, bone morphogenetic proteins, epidermal growth factor and fibroblast growth factor is primarily employed by these pathways in the eventual cascade of events. The different aberrations in such cell-signaling processes trigger the onset of respiratory diseases making the conventional therapeutic modalities ineffective. These challenges have prompted us to explore novel and effective approaches for the prevention and/or treatment of respiratory diseases. In this review, we have attempted to deliberate on the current literature describing the role of major cell signaling pathways in the pathogenesis of pulmonary diseases and discuss promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing pulmonary vascular pathology in such patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.