Going Beyond Antibiotics: Natural Plant Extracts as an Emergent Strategy to Combat Biofilm-Associated Infections

Kou J 1 , Xin TY 1 , McCarron P 2 , Gupta G 3 , Dureja H 4 , Satija S 5 Show all authors , Mehta M 6 , Bakshi HA 2 , Tambuwala MM 7 , Collet T 8 , Dua K 9 , Chellappan DK 10

Affiliations 

  • 1 School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
  • 2 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, United Kingdom
  • 3 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Jaipur, India
  • 4 Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana 124001, India
  • 5 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, New South Wales, Australia
  • 6 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia
  • 7 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine County, Londonderry, BT52 1SA, Northern Ireland, United Kingdom
  • 8 Indigenous Medicines Group, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, Queensland 4059, Australia
  • 9 Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, NSW 2308, Australia; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, New South Wales, Australia
  • 10 Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
J Environ Pathol Toxicol Oncol, 2020;39(2):125-136.
PMID: 32749122 DOI: 10.1615/JEnvironPatholToxicolOncol.2020032665

Abstract

Biofilms are a collective of multiple types of bacteria that develop on a variety of surfaces. Biofilm development results in heightened resistance to antibiotics. Quorum sensing plays an important role in biofilm development as it is one of the common communication mechanisms within cells, which balances and stabilizes the environment, when the amount of bacteria increases. Because of the important implications of the roles biofilms play in infectious diseases, it is crucial to investigate natural antibacterial agents that are able to regulate biofilm formation and development. Various studies have suggested that natural plant products have the potential to suppress bacterial growth and exhibit chemopreventive traits in the modulation of biofilm development. In this review, we discuss and collate potential antibiofilm drugs and biological molecules from natural sources, along with their underlying mechanisms of action. In addition, we also discuss the antibiofilm drugs that are currently under clinical trials and highlight their potential future uses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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