Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome

Altamish M 1 , Dahiya R 2 , Singh AK 1 , Mishra A 3 , Aljabali AAA 4 , Satija S 5 Show all authors , Mehta M 6 , Dureja H 7 , Prasher P 8 , Negi P 9 , Kapoor DN 9 , Goyal R 9 , Tambuwala MM 10 , Chellappan DK 11 , Dua K 12 , Gupta G 13

Affiliations 

  • 1 Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India
  • 2 Laboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
  • 3 School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • 4 Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid, 21163, Jordan
  • 5 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, New South Wales, Australia
  • 6 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia
  • 7 Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana 124001, India
  • 8 Department of Chemistry, University of Petroleum and Energy Studies, Dehradun, 248007, India
  • 9 School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India
  • 10 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine County, Londonderry, BT52 1SA, Northern Ireland, United Kingdom
  • 11 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia 57000
  • 12 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, University of Newcastle (UoN), Callaghan, NSW 2308, Australia
  • 13 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Jaipur, India
Crit Rev Eukaryot Gene Expr, 2020;30(3):245-252.
PMID: 32749111 DOI: 10.1615/CritRevEukaryotGeneExpr.2020033451

Abstract

Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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