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Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Bakshi HA 1 , Zoubi MSA 2 , Hakkim FL 3 , Aljabali AAA 4 , Rabi FA 5 , Hafiz AA 6 Show all authors , Al-Batanyeh KM 7 , Al-Trad B 7 , Ansari P 8 , Nasef MM 9 , Charbe NB 10 , Satija S 11 , Mehta M 11 , Mishra V 11 , Gupta G 12 , Abobaker S 13 , Negi P 14 , Azzouz IM 15 , Dardouri AAK 16 , Dureja H 17 , Prasher P 18 , Chellappan DK 19 , Dua K 20 , Webba da Silva M 1 , El Tanani M 21 , McCarron PA 1 , Tambuwala MM 1

Affiliations 

  • 1 School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK
  • 2 Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 566, Jordan
  • 3 Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, Salalah 211, Oman
  • 4 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 566, Jordan
  • 5 Department of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan
  • 6 Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21421, Saudi Arabia
  • 7 Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 566, Jordan
  • 8 School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, UK
  • 9 Department of Pharmacy and Biomedical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD13DH, UK
  • 10 Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O'Higgins, Santiago 340, Región Metropolitana, Chile
  • 11 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
  • 12 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, Rajasthan 302017, India
  • 13 Department of Gynecology, European Competence Center for Ovarian Cancer, Campus Virchow, Klinikum Charite-Universitatmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • 14 School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173229, India
  • 15 Department of Dermatology, Venerology, and Allergology, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Chariteplatz1, 10117 Berlin, Germany
  • 16 Department of Forensic Science, School of Applied Sciences, University of Huddersfield, Huddersfield HD13DH, UK
  • 17 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India
  • 18 Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India
  • 19 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • 20 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia
  • 21 Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan
Nutrients, 2020 06 26;12(6).
PMID: 32604971 DOI: 10.3390/nu12061901

Abstract

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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