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Targeting LIN28: a new hope in prostate cancer theranostics

Shrivastava G 1 , Aljabali AA 2 , Shahcheraghi SH 3 , Lotfi M 3 , Shastri MD 4 , Shukla SD 5 Show all authors , Chellappan DK 6 , Jha NK 7 , Anand K 8 , Dureja H 9 , Pabari RM 10 , Mishra V 11 , Almutary AG 12 , Alnuqaydan AM 12 , Charbe N 13 , Prasher P 14 , Negi P 15 , Goyal R 15 , Dua K 16 , Gupta G 17 , Serrano-Aroca Á 18 , Bahar B 19 , Barh D 20 , Panda PK 21 , Takayama K 22 , Lundstorm K 23 , McCarron P 24 , Bakshi H 24 , Tambuwala MM 24

Affiliations 

  • 1 Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India
  • 2 Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid-Jordan
  • 3 Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • 4 School of Pharmacy & Pharmacology, University of Tasmania, Hobart, Australia
  • 5 Priority Research Centre for Healthy Lungs, School of Medicine & Public Health, The University of Newcastle, Callaghan, Australia
  • 6 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
  • 7 Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India
  • 8 Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences & National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa
  • 9 Department of Chemistry, School of Science, GITAM University, Hyderabad 502329, India
  • 10 RCSI, University of Medicine & Health Sciences, Dublin, Ireland
  • 11 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
  • 12 Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia
  • 13 Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 340, Región Metropolitana, Chile
  • 14 Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India
  • 15 School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173229, India
  • 16 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Australia
  • 17 School of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, India
  • 18 Biomaterials & Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia, San Vicente Mártir, Valencia 46001, Spain
  • 19 International Institute of Nutritional Sciences & Food Safety Studies, University of Central Lancashire, Preston, United Kingdom
  • 20 Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • 21 Condensed Matter Theory Group, Materials Theory Division, Department of Physics & Astronomy, Uppsala University, Uppsala 75120, Sweden
  • 22 Center for IPS Cell Research & Application, Kyoto University, Kyoto 606-8397, Japan
  • 23 PanTherapeutics, Lutry CH1095, Switzerland
  • 24 School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, UK
Future Oncol, 2021 Oct;17(29):3873-3880.
PMID: 34263659 DOI: 10.2217/fon-2021-0247

Abstract

The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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